陈道梅

博士，副研究员，硕士生导师

邮箱：310370301@qq.com 电话：13888021660（微信同号）

主要从事模拟蛋白酶、抗肿瘤等功能性生物材料的研究工作，2017年入选“东陆中青年骨干教师”培养计划。主持云南省应用基础研究计划项目、云南省教育厅资助性项目以及横向项目。发表SCI期刊论文20余篇，授权专利5项（其中2项美国发明专利）。

教育和工作经历

2022-11至今，澳门永利集团3044，副研究员

2016-08 至2022-11, 澳门永利集团3044，助理研究员

2013-09 至 2016-06, 澳门永利集团3044, 物理化学, 博士

2010-09 至 2013-06, 澳门永利集团3044, 无机化学, 硕士

2003-09 至 2007-06, 兰州理工大学, 食品科学与工程专业, 学士

研究领域

从事模拟酶生物材料和抗肿瘤生物材料研究，包括金属-有机骨架材料、碳量子点材料、纳米复合材料、多孔碳材料、单原子材料等。

科研与教学情况

1. CQDs/Cu₂O下调肿瘤细胞金属基质蛋白酶研究, 云南省应用基础研究面上项目, 2018FB013, 2018-06至2021-05, 10万元, 已结题, 主持

2. MOFs材料的细胞毒性及其抑制细胞迁移的研究, 云南省教育厅资助性项目, 2017ZZX223, 2017-01至2019-01, 4万元, 已结题, 主持

3. 仿生材料和长波红外光谱仪在烟用香精香料分析中的应用，云南中烟工业有限责任公司开放课题，2021-11至2023-11，47万元，在研，主持

主要学术成果

（一）代表性论文

[1] Xiaoyi Dong, Liang Xu, Junhao Ma, Yongjin Li,* Zhaoyi Yin, Daomei Chen,* Qi Wang, Jin Han, Jianbei Qiu, Zhengwen Yang, Zhiguo Song, * Enhanced interfacial charge transfer and photothermal effect via in-situ construction of atom co-sharing Bi plasmonic/Bi4O₅Br₂ nanosheet heterojunction towards improved full-spectrum photocatalysis, Chemical Engineering Journal, 2023, 459,141557.

[2] Yongjin Li,* Junhao Ma, Liang Xu, Tong Liu, Taizhong Xiao, Daomei Chen,* Zhiguo Song, Jianbei Qiu, Yueli Zhang.* Enhancement of charge separation and NIR light harvesting through construction of 2D–2D Bi₄O₅I₂/BiOBr: Yb³⁺, Er³⁺ Z‐scheme heterojunctions for improved full‐spectrum photocatalytic performance. 2023, Advanced Science, 2207514.

[3] Daomei Chen, Liang Jiang, Tao Lei, Guo Xiao, Yuanfeng Wang, Xiaoqiong Zuo, Bin Li, Lingli Li and Jiaqiang Wang.* Magnetic CuFe₂O₄ with intrinsic protease-like activity inhibited cancer cell proliferation and migration through mediating intracellular proteins, Biomaterials and Biosystems, 100038, 2022.

[4] Daomei Chen, Bin Li, * Tao Lei, Di Na, Minfang Nie, Yepeng Yang, Congjia Xie, Zijuan He and Jiaqiang Wang.* Selective mediation of ovarian cancer SKOV3 cells death by pristine carbon quantum dots/ Cu₂O composite through targeting matrix metalloproteinases, angiogenic cytokines and cytoskeleton, Journal of Nanobiotechnology, 2021,19(1), 1-17.

[5] Daomei Chen, Bin Li,* Liang Jiang, Yizhou Li, Yepeng Yang, Zhifang Luo and Jiaqiang Wang.* Pristine Cu-MOF Induces Mitotic Catastrophe and Alterations of Gene Expression and Cytoskeleton in Ovarian Cancer Cells. ACS Applied Bio Materials, 2020, 3, 4081-4094.

[6] Daomei Chen, Bin Li,* Liang Jiang, Deliang Duan, Yizhou Li, Jiaqiang Wang,* Jiao He and Yanbo Zeng. Highly efficient colorimetric detection of cancer cells utilizing Fe-MIL-101 with intrinsic peroxidaselike catalytic activity over a broad pH range, RSC Advances, 2015, 5, 97910-97917.

[7] Mengfan Wang, Rong Yang, Shijie Tang, Yuang Deng, Guokui Li, Dan Zhang, Daomei Chen, Xiaoxia Ren, Feng Gao, In vivo realization of dual photodynamic and photothermal therapy for melanoma by mitochondria targeting dinuclear ruthenium complexes under civil infrared low-power laser, Angewandte Chemie International Edition, 2022, 61(38): e202208721.

[8] Bin Li, Daomei Chen, Minfang Nie, Jiaqiang Wang,* Yizhou Li and Yepeng Yang. Carbon dots/Cu₂O composite with intrinsic high protease-like activity for hydrolysis of proteins under physiological conditions. Particle & Particle Systems Characterization, 2018, 1800277.

[9] Jiaqiang Wang,* Daomei Chen, Bin Li,* Jiao He, Deliang Duan, Dandan Shao and Minfang Nie. Fe-MIL-101 exhibits selective cytotoxicity and inhibition of angiogenesis in ovarian cancer cells via downregulation of MMP. Scientific Reports, 2016, 6: 26126.

[10] Bin Li,* Daomei Chen, Jiaqiang Wang,* Zhiying Yan, Liang Jiang, Deliang Duan, Jiao He, Zhongrui Luo, Jinping Zhang and Fagui Yuan. MOFzyme: Intrinsic protease-like activity of Cu-MOF, Scientific Reports, 2014, 4, 6759.

[11]Xu-Dan Bi, Rong Yang, Yue-Chen Zhou, Daomei Chen, Guo-Kui Li, Yuan-Xiao Guo, Meng-Fan Wang, Dandan Liu,* and Feng Gao. Cyclometalated iridium(III) complexes as h-sensitivity two-photon excited mitochondria dyes and near-infrared photodynamic therapy agents[J]. Inorganic Chemistry, 2020, 59(20), 14920-14931.

（二）授权专利

[1] Bin Li, Daomei Chen, Jiaqiang Wang, Minfang Nie. Use of metal-organic framework as tumor angiogenesis inhibitor，US10，653，702，B2, 2020-05-08.

[2] Jiaqiang Wang, Ying Li, Daomei Chen, Method for synthesizing 4-(hydroxumethyl) benzoic acid by using P-Xylene (PX) as raw material, US10, 669, 223, B2, 2020-06-02.

[3] 王家强, 李应, 陈道梅. 一种以对二甲苯（PX）为原料合成对羟甲基苯甲酸的方法，专利号：ZL201710451197.4, 2020-07-28.

[4] 李斌, 陈道梅, 王家强．一种金属有机骨架化合物抗肿瘤血管生成剂及其使用方法,专利号：ZL201610299834.6, 2021-01-29.

[5] 李斌, 陈道梅, 王家强, 聂敏芳. 一种蛋白质水解催化剂碳量子点/氧化亚铜复合物（Cu₂O/CQDs）及其应用，专利号：201710805774.5, 2020-06-23.